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Notice that MTHFR is in a key spot, tying together 5-methyltetrahydrofolate and homocysteine

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However, it is important to note that the clinical significance of these increases remains uncertain

This comparison requires major caveats, since GLP-1 medications are not approved for endometriosis and the evidence base is incomparable

This insight, which implied that a substance could be harmful at a high dose but beneficial or benign at a low one, directly prefigured the biphasic dose-responses central to hormesis and laid the groundwork for modern toxicology

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